Role of 11beta-hydroxysteroid dehydrogenase in bone metabolism / 中国组织工程研究
Chinese Journal of Tissue Engineering Research
; (53): 5203-5208, 2017.
Article
em Zh
| WPRIM
| ID: wpr-668345
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
Glucocorticoids play an essential role in osteoblast differentiation, but excessive glucocorticoids will inhibit the osteoblastic phenotype. Regulation of 11β-hydroxysteroid dehydrogenase (11β-HSD) contributes to optimizing the effect of glucocorticoids.OBJECTIVE:
To summarize the effect of 11β-HSD in bone metabolism.METHODS:
The corresponding author retrieved PubMed and CJFD databases for the articles published before 2016 using the keywords "11β-HSD, bone" in English and Chinese, respectively. Totally 115 articles were retrieved, including 98 English and 17 Chinese articles, and finally 45 eligible articles were included in accordance with the inclusion criteria.RESULTS ANDCONCLUSION:
Glucocorticoid action can be regulated at prereceptor level by 11β-HSD. 11β-HSD1 activity may predict individual susceptibility to glucocorticoids, which instructs the individualized application of glucocorticoids precisely. 11β-HSD1 activity is closely related to osteoblast differentiation and the presence of an intrinsic differentiation-driven molecular switch inhibits the activity of 11β-HSD1. Instead of regulating the mesenchymal progenitors directly, gucocorticoids regulate the mesenchymal progenitors to differentiate into cranial skeleton mainly through mature osteoblasts. Short-term glucocorticoid exposure directly increases 11β-HSD1 activity and continuous exposure to glucocorticiod indirectly inhibits 11β-HSD1 activity.
Texto completo:
1
Base de dados:
WPRIM
Tipo de estudo:
Prognostic_studies
Idioma:
Zh
Revista:
Chinese Journal of Tissue Engineering Research
Ano de publicação:
2017
Tipo de documento:
Article