The effect of simvastatin on bone formation during the retention after orthodontic tooth movement / 实用口腔医学杂志
Journal of Practical Stomatology
; (6)1995.
Article
em Zh
| WPRIM
| ID: wpr-670891
Biblioteca responsável:
WPRO
ABSTRACT
Objective:To investigate the effect of of simvastatin on bone formation and bone mineral density(BMD) during the retention after orthodontic tooth movement. Methods:Orthodontic tooth movement of upper first molar was performed in 40 rats with coil spring for 21 days. 40 rats were randomly allocated into 5 groups: basic control group,negative control group and 3 simvastatin groups(2.5 mg?kg-1, 5.0 mg?kg-1 and 10.0 mg?kg-1respectively).Rats in basic control group were killed when appliances were removed after 21 days.The experimental groups were administered simvastatin daily from 1 day before appliances removed for 4 weeks.The negative control group received the isotonic saline as control.4 weeks later all animals were anesthetized and killed. Level of serum Ca and P in blood, ALP, BGP and BMD were monitored.Results:①Between experimental groups and the negative control group, in amounts of ALP and BGP,the anterior were higher than the posterior (P0.05). ②The alveolar near the maxillary first molar,BMD of the basic control group was the highest(P
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Journal of Practical Stomatology
Ano de publicação:
1995
Tipo de documento:
Article