Detection of hepatitis C virus RNA in bone marrow mononuclear cells by digoxin-labeled in situ hybridization / 中华传染病杂志
Chinese Journal of Infectious Diseases
; (12)1997.
Article
em Zh
| WPRIM
| ID: wpr-677090
Biblioteca responsável:
WPRO
ABSTRACT
To investigate HCV extrahepiatic infection and replication site as well as its relation with liver damage,bone-marrow mononuclear cells from 20 cases of nutreated chronic hepatitis C virus infect- ed patients were studied by digoxin-labeled in situ hybridization.Positive HCV RNA stained were de- tected in 18 of 20 cases (90%).Negative HCV RNA stained were not detected in any cases.The results suggested that there was HCV RNA in the bone-marrow of the patients with hepatitis C and bone-mar- row could be infected by HCV.But bone-marrow cell is not the HCV replication site.This study has some significance in HCV elucidating the pathogenicity of as well as the pathogenesis of chronic hepatitis C.
Texto completo:
1
Base de dados:
WPRIM
Tipo de estudo:
Diagnostic_studies
Idioma:
Zh
Revista:
Chinese Journal of Infectious Diseases
Ano de publicação:
1997
Tipo de documento:
Article