Effect of hyperbaric oxygen on apoptosis in CA_1 pyramidal cell layer of gerbil hippocampus following forebrain ischemia reperfusion injury / 第二军医大学学报

ABSTRACT

Objective: To investigate the changes of neuronal apoptosis induced by ischemia reperfusion in gerbil hippocampus CA 1 after hyperbaric oxygen(HBO) treatment, and to study the effects of HBO on the treatment of cerebral ischemia. Methods: Ischemia reperfusion model of gerbil was established. The effects of HBO treatment for 3 succesive days on neuronal apoptosis of hippocampus CA 1 were examined using H E and TUNEL staining methods. Results: The number of neuronal apoptosis in hippocampus CA 1 was significantly decreased in HBO treatment groups ( P