INFLUENCE OF TAURINE ON LEARNING AND MEMORY CYTOKINES IN RATS INTRAHIPPOCAMPALLY INJECTED WITH ?-AMYLOID / 营养学报
Acta Nutrimenta Sinica
; (6)1956.
Article
em Zh
| WPRIM
| ID: wpr-679192
Biblioteca responsável:
WPRO
ABSTRACT
Objective:
To investigate the effect of taurine on learning and memory impairment, cytokines secretion in rats intrahippocampally injected with ?-amyloid (A?) 1-40.Methods:
SD rats were randomly divided into control group, A? injected group, taurine (0.3g/kg?d, 0.6g/kg?d) groups. The rats were fed with taurine for 7 days, and then subjected to bilateral intrahippocampus injection of A?1-40 or vehicle. Two weeks later, all rats performed Morris water maze test. The contents of IL-6, TNF-? were checked by way of radio-immunity assay for hippocampus samples.Results:
Compared with A?model group, the escape latency and distance were significantly reduced in taurine (0.6g/kg?d) group; the ratio of swimming distance in the target quadrant to that in the whole pool of the probe trial; the content of cytokines of IL-6 and TNF-?in hippocampus were reduced significantly.Conclusion:
Taurine can effectively attenuate the cognitive dysfunction caused by A?1-40 in rats. The reduced cytokines content in hippocampus might contribute to this effect.
Texto completo:
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Acta Nutrimenta Sinica
Ano de publicação:
1956
Tipo de documento:
Article