Expression and significance of P-cadherin,E-cadherin,and β-catenin in colon polyps / 国际检验医学杂志

ABSTRACT

Objective To explore the expressions and significance of P-cadherin(P-ca),E-cadherin(E-ca), and β-catenin(β-ca)in colon polyps.Methods A total of 120 patients with colon polyps were selected and di-vided into the hyperplastic polyp group(40 cases),the tubular adenoma group(40 cases)and the villous adeno-ma group(40 cases).Other 20 healthy normal persons in the same period were selected as the control group. Immunohistochemistry(S-P)method was used to detect the expressions of P-ca,E-ca,and β-ca of subjects in paraffin sections of colonic polyp tissue and normal colonic mucosa.Western blotting semiquantitative method was used to detect the expression levels of P-ca,E-ca,and β-ca protein.Results P-ca was almost not express-ing in normal colonic mucosa,and positive signals in colon polyps tissue located in the cytoplasm and cell mem-brane,with the progression of the positive expression rate,it gradually increased(P<0.05).Positive-expres-sion of E-ca was in the cell membrane,with the progress of the disease,the positive-expression rate significant-ly decreased(P<0.05),β-ca expressed on the cell membrane in normal colonic mucosa tissue,with cytoplasmic of nuclear ectopic expression in the colon polyps group,with the progress of the disease,the positive rate of cytoplasm of nucleus gradually increased(P<0.05).Conclusion P-ca and β-ca show up-regulated expression in colon polyps,and E-ca show down-regulate expression,these three indicators were related closely to the oc-currence and development of colon polyps.