Research progress of neonatal hypoxic-ischemic encephalopathy treatment with mesenchymal stem cells / 中华实用儿科临床杂志

ABSTRACT

Neonatal hypoxic-ischemic encephalopathy (HIE) can result in serious outcomes including death during the newborn period and later neuropsychological handicaps.So far,there have been no obvious effect on the improvement of prognosis with traditional treatments,and the cryogenic treatment is the most effective treatment for the past decade,while the clinical application is limited by age and disease course.At present,stem cell transplantation in the treatment of HIE is the new direction,of which the mesenchymal stem cells are outstanding by its easy materials,low immunogenicity and potential nerve regeneration properties.This paper reviews and updates the progress of mesenchymal stem cell transplantation for neonatal HIE.