Comparison of 5-year outcomes of zotarolimus-eluting stents and everolimus-eluting stents / 中国介入心脏病学杂志

ABSTRACT

Objective To compare 5-year clinical outcomes of the safety and efficacy of zotarolimus-eluting stent(ZES)and everolimus-eluting stent(EES).Methods A total of 480 patients receiving either ZES(n=244)or EES(n=236)placement from January 2011 to December 2012 in Wuhan Asia Heart Hospital were included in this study.The primary end point of the study was 5-year all-cause mortality including acute myocardial infarction,and target vessel revascularization after the index EES/ZES placement.The secondary end points included subsequent in-stent restenosis and in-stent occlusion at 5 years.Results There were no significant differences in all-cause mortality and acute myocardial infarction outcomes between the ZES and the EES groups(P＞0.05).Compared with patients receiving EES,patients receiving ZES had a significantly higher rate of 5-year target vessel revascularization(10.2％vs.5.1％,P=0.040),in-stent restenosis(11.5％vs.5.9％,P=0.036),and in-stent occlusion(6.1％vs.2.1％,P=0.038).Conclusions At 5 years,patients receiving EES generally had better or comparable long-term outcomes compared with patients receiving ZES.