Formula Optimization of Aprepitant Nanocapsules by Central Composite Design-response Surface Method-ology / 中国药师
China Pharmacist
; (12): 232-236, 2018.
Article
em Zh
| WPRIM
| ID: wpr-705496
Biblioteca responsável:
WPRO
ABSTRACT
Objective:
To optimize the formula of aprepitant nanocapsules.Methods:
The central composite design–response surface methodology was used. The amounts of hydroxg propyl cellulose(HPC-SL) and sodium dodecyl sulfate(SDS) were set as the independent variables;the dissolution of aprepitant capsules at 15min and 30min, and the dissolution after accelerated at 40℃ and 75% RH for 6 months were set as the dependent variables. Quadratic polynomial mathematic models were used to evaluate the relation-ship between the independent and the dependent variables. According to the mathematic models,an effect graph was drawn. The opti-mized formula was chosen from the overlap of the contour graphs of the dependent variables. The similarity of in vitro dissolution curve was evaluated by using f2factor.Results:
The correlation coefficient of quadratic polynomial mathematic model and the reliability was high. The measured values of the optimized formula were within the expected ranges.Conclusion:
Aprepitant nanocapsules with the optimized formula by central composite design-response surface methodology meet the requirements. The results can provide evidence for the next industrial production.
Texto completo:
1
Base de dados:
WPRIM
Tipo de estudo:
Prognostic_studies
Idioma:
Zh
Revista:
China Pharmacist
Ano de publicação:
2018
Tipo de documento:
Article