Radioprotective effects of resveratrol and its mechanism / 中华放射医学与防护杂志

ABSTRACT

Resveratrol is a kind of natural active substance,which has strong antioxidant activity and radioprotective effect.A large number of tests have shown that resveratrol can attenuates radiation damage and play an important role in radiation protection,has a good application prospects.This paper reviews the radioprotective effects of resveratrol on the hematopoietic system,the immune system,the nervous system,the respiratory system,and other devices and their mechanisms of action.Including the HO1 signaling pathway,Nrf2 pathway and other antioxidant mechanisms and the activation of Sirt1 regulate the downstream signals,promote TyrRs into the nucleus to play the role of radioprotection.The prospect of application of resveratrol was also prospected.