Serum Fibroblast Growth Factor 21 and New-Onset Metabolic Syndrome: KoGES-ARIRANG Study
Yonsei Medical Journal
; : 287-293, 2018.
Article
em En
| WPRIM
| ID: wpr-713091
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
Fibroblast growth factor 21 (FGF21) is a crucial metabolic regulator, with multiple favorable effects on glucose homeostasis and lipid metabolism. Since serum FGF21 level has been implicated as a potential marker for the early identification of metabolic syndrome (MetS), we investigated the association between serum FGF21 level and the development of MetS in a population-based prospective study. MATERIALS ANDMETHODS:
We conducted a prospective study of 221 randomly sampled adults without MetS from a general population-based cohort study who were examined from 2005–2008 (baseline) and from 2008–2011 (follow-up). Baseline serum FGF21 levels were analyzed using enzyme-linked immunosorbent assay.RESULTS:
During the average 2.8-year follow-up period, 82 participants (36.6%) developed new-onset MetS. Serum FGF21 levels were significantly higher in patients with new-onset MetS than in those without MetS (209.56±226.80 vs. 110.09±81.10, p < 0.01). In multivariate adjusted models, the odds for MetS development were greater in patients with serum FGF21 levels in the highest quartile, compared to those in the lowest quartile (3.84, 95% confidence interval 1.59–9.28).CONCLUSION:
Serum FGF21 level was an independent predictor for new-onset MetS in a population-based prospective study.Palavras-chave
Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Biomarcadores
/
Razão de Chances
/
Análise Multivariada
/
Estudos Prospectivos
/
Síndrome Metabólica
/
Fatores de Crescimento de Fibroblastos
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Yonsei Medical Journal
Ano de publicação:
2018
Tipo de documento:
Article