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Association of Norepinephrine Transporter Gene and Side Effects of Osmotic-Release Oral System Methylphenidate in Attention-Deficit Hyperactivity Disorder
Article em Ko | WPRIM | ID: wpr-7138
Biblioteca responsável: WPRO
ABSTRACT

OBJECTIVES:

The aim of our study was to investigate association of norepinephrine transporter gene (SLC6A2) polymorphism and side effects of osmotic-release oral system methylphenidate (OROS MPH) in children with attention-deficit hyperactivity disorder (ADHD).

METHODS:

We recruited drug naive children with ADHD (N=97). We administered OROS MPH by tolerable dosage. At week 8 of treatment, parents completed the Barkley's side effect rating scale. We analyzed two SLC6A2 single nucleotide polymorphisms (SNPs), rs192303 and rs3785143, with blood of subjects. We compared the frequency and severity of each side effect among SLC6A2 genotypes of 2 SNPs.

RESULTS:

In the analysis of frequency of each side effect, irritability differed according to rs192303 and rs3785143 genotype. In comparisons of severity, talking less and disinterest differed according to rs192303 genotype. In the case of rs3785143, severities of disinterest and irritability were involved with genotype.

CONCLUSION:

Side effects of OROS MPH showed an association with SLC6A2 genotype.
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Texto completo: 1 Base de dados: WPRIM Assunto principal: Pais / Polimorfismo de Nucleotídeo Único / Proteínas da Membrana Plasmática de Transporte de Norepinefrina / Genótipo / Metilfenidato Limite: Child / Humans Idioma: Ko Revista: Journal of the Korean Academy of Child and Adolescent Psychiatry Ano de publicação: 2014 Tipo de documento: Article
Texto completo: 1 Base de dados: WPRIM Assunto principal: Pais / Polimorfismo de Nucleotídeo Único / Proteínas da Membrana Plasmática de Transporte de Norepinefrina / Genótipo / Metilfenidato Limite: Child / Humans Idioma: Ko Revista: Journal of the Korean Academy of Child and Adolescent Psychiatry Ano de publicação: 2014 Tipo de documento: Article
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