Non-convulsive seizure related to Cremophor EL™-free, polymeric micelle formulation of paclitaxel: a case report
Obstetrics & Gynecology Science
; : 421-424, 2018.
Article
em En
| WPRIM
| ID: wpr-714698
Biblioteca responsável:
WPRO
ABSTRACT
Paclitaxel is a chemotherapeutic agent that is effective against ovarian, breast, lung, and other cancers. Although peripheral neurotoxicity is among the most common side effects of paclitaxel treatment, central neurotoxicity is rarely reported. When centrally mediated side effects are observed, they are attributed to Cremophor EL™ (CrEL), a surfactant-containing vehicle used for paclitaxel administration. In the present report, we discuss the case of a 72-year-old woman with ovarian carcinoma who experienced a non-convulsive seizure following administration of a CrEL-free, polymeric micelle formulation of paclitaxel. One week after her fourth round of chemotherapy, she experienced a transient episode of aphasia for 45 minutes. Electroencephalography demonstrated epileptiform discharges. To our knowledge, this is the first reported case of seizure associated with a CrEL-free formulation of paclitaxel. Although rare, patients and clinicians should remain aware of the risk of non-convulsive seizure following infusion of this paclitaxel formulation.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Afasia
/
Polímeros
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Convulsões
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Mama
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Paclitaxel
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Tratamento Farmacológico
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Eletroencefalografia
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Pulmão
Limite:
Aged
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Female
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Humans
Idioma:
En
Revista:
Obstetrics & Gynecology Science
Ano de publicação:
2018
Tipo de documento:
Article