Multiple Markers of Contrast Induced Nephropathy after the Percutaneous Coronary Intervention
Soonchunhyang Medical Science
; : 15-21, 2018.
Article
em En
| WPRIM
| ID: wpr-715119
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
Contrast-induced nephropathy (CIN) frequently occurs after percutaneous intervention. Objective of this study was to investigate the usefulness of serum cystatin C, neutrophil gelatinase-associated lipocalcin (NGAL), urinary kidney injury molecule-1 (KIM-1), and interleukin-18 (IL-18) as early predictors for CIN after percutaneous coronary intervention (PCI).METHODS:
In 53 patients who underwent PCI were enrolled. Serum creatinine and cystatin C level were measured immediately before, and 24 hours and 48 hours after catheterization. Serum NGAL, urinary KIM-1, and IL-18 were measured immediately before, and 4 hours, 24 hours, and 48 hours after catheterization. CIN was defined as a rise in creatinine 0.5 mg/dL or 25% above baseline.RESULTS:
CIN occurred in four patients (7.5%). Serum cystatin C levels were higher at 24 hours and 48 hours in CIN patients than in those without CIN (P<0.05). Serum NGAL levels were higher at 48 hours in CIN patients than in those without CIN. Urinary KIM-1 levels were higher at 48 hours in CIN patients than in those without CIN. There were no significant markers of CIN on multi-variate analysis.CONCLUSION:
In this study, the occurrence of CIN after PCI was 7.5%. Although there were some time-course changes in serum cystatin C and urinary KIM-1 after PCI, there was no significant predictor for CIN after PCI.Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Cateterismo
/
Meios de Contraste
/
Interleucina-18
/
Creatinina
/
Cistatina C
/
Catéteres
/
Intervenção Coronária Percutânea
/
Rim
/
Neutrófilos
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Soonchunhyang Medical Science
Ano de publicação:
2018
Tipo de documento:
Article