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Combination of Tumor Volume and Epstein-Barr Virus DNA Improved Prognostic Stratification of Stage II Nasopharyngeal Carcinoma in the Intensity Modulated Radiotherapy Era: A Large-Scale Cohort Study / Journal of the Korean Cancer Association, 대한암학회지
Article em En | WPRIM | ID: wpr-715971
Biblioteca responsável: WPRO
ABSTRACT

PURPOSE:

Little is known about combination of the circulating Epstein-Barr viral (EBV) DNA and tumor volume in prognosis of stage II nasopharyngeal carcinoma (NPC) patients in the intensity modulated radiotherapy (IMRT) era. We conducted this cohort study to evaluate the prognostic values of combining these two factors. MATERIALS AND

METHODS:

By Kaplan-Meier, we compare the differences of survival curves between 385 patients with different EBV DNA or tumor volume levels, or with the combination of two biomarkers mentioned above.

RESULTS:

Gross tumor volume of cervical lymph nodes (GTVnd, p 0 copy/mL, GTVtotal 0 copy/mL, GTVtotal ≥ 30 cm³). When patients in the low-risk group were compared with those in the high-risk group, 3-year PFS (p=0.003), LRFS (p=0.010), and DMFS (p=0.031) rates were statistically significant.

CONCLUSION:

Pretreatment plasma EBV DNA and tumor volume were both closely correlated with prognosis of stage II NPC patients in the IMRT era. Combination of EBV DNA and tumor volume can refine prognosis and indicate for clinical therapy.
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Texto completo: 1 Base de dados: WPRIM Assunto principal: Plasma / Prognóstico / Radioterapia / DNA / Biomarcadores / Nasofaringe / Estudos de Coortes / Herpesvirus Humano 4 / Carga Tumoral / Linfonodos Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Cancer Research and Treatment Ano de publicação: 2018 Tipo de documento: Article País de publicação: COREA DEL SUR / COREIA DO SUL / KR / SOUTH KOREA
Texto completo: 1 Base de dados: WPRIM Assunto principal: Plasma / Prognóstico / Radioterapia / DNA / Biomarcadores / Nasofaringe / Estudos de Coortes / Herpesvirus Humano 4 / Carga Tumoral / Linfonodos Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Cancer Research and Treatment Ano de publicação: 2018 Tipo de documento: Article País de publicação: COREA DEL SUR / COREIA DO SUL / KR / SOUTH KOREA