The Diagnostic Performance of Liver MRI without Intravenous Contrast for Detecting Hepatocellular Carcinoma: A Case-Controlled Feasibility Study
Korean Journal of Radiology
; : 568-577, 2018.
Article
em En
| WPRIM
| ID: wpr-716278
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
To preliminarily evaluate the diagnostic performance of an unenhanced MRI for detecting hepatocellular carcinoma (HCC) with a case-control study design. MATERIALS ANDMETHODS:
The case group consisted of 175 patients with initially-diagnosed HCC, who underwent a 3T liver MRI. A total of 237 HCCs were identified. The number of HCCs that were smaller than 1 cm, 1 cm ≤ and < 2 cm, and ≥ 2 cm were 19, 105, and 113, respectively. For the control group, 72 patients with chronic liver disease, who did not have HCC, were enrolled. Two radiologists independently reviewed the T2 half-Fourier acquisition single-shot turbo spin echo, T2 fast spin echos with fat saturation, T1 gradient in- and out-of-phase images, and diffusion-weighted images/apparent diffusion coefficient maps to detect HCC. Per-patient analyses were performed to evaluate the sensitivity and specificity of the non-contrast MRI for diagnosing HCC. Furthermore, the per-lesion sensitivity was also calculated according to tumor size.RESULTS:
In the per-patient analyses, the sensitivity and specificity of reader 1 were 86.3% (151/175) and 87.5% (63/72), respectively; while those of reader 2 were 82.9% (145/175) and 76.4% (55/72), respectively. When excluding HCCs smaller than 1 cm, the sensitivity of reader 1 and 2 were 88.0% (147/167) and 86.2% (144/167), respectively. In the per-lesion analyses, the sensitivities of reader 1 and reader 2 were 75.9% (180/237) and 70.5% (167/237), respectively.CONCLUSION:
The per-patient sensitivity and specificity of non-contrast MRIs were within a reasonable range for the initial diagnosis of HCC. Non-contrast MRIs may have a potential for surveillance of HCC. Further confirmatory diagnostic test accuracy studies are needed.Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Imageamento por Ressonância Magnética
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Estudos de Casos e Controles
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Estudos de Viabilidade
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Programas de Rastreamento
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Sensibilidade e Especificidade
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Carcinoma Hepatocelular
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Diagnóstico
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Testes Diagnósticos de Rotina
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Difusão
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Fígado
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Screening_studies
Limite:
Humans
Idioma:
En
Revista:
Korean Journal of Radiology
Ano de publicação:
2018
Tipo de documento:
Article