Diverse Ischemic Postconditioning Protocols Affect the Infarction Size in Focal Ischemic Stroke
Journal of Cerebrovascular and Endovascular Neurosurgery
; : 159-167, 2018.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-717045
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
Ischemic postconditioning (IPostC), consisted of transient brain ischemia/reperfusion cycles, is considered to have neuroprotective effect. However, there is no best single protocol of IPostC, because varied factors like species tested and characteristics of the tissue may affect the efficacy of IPostC. Thus, we investgated whether different protocols of IPostC affect neuroprotective effects in experimental animal models. MATERIALS ANDMETHODS:
Through occlusion of middle cerebral artery (MCA) with intraluminal suture, stroke was induced in a transient focal ischemia model in mice. We conducted IPostC via brief and repeated MCA occlusion, 2 minutes after reperfusion, followed by different ischemia and reperfusion protocols. After procedure, functional neurological score and histological examination were evaluated.RESULTS:
IPostC with different protocols resulted in diverse effects. Among them, a protocol that consists of 3 cycle of IPostC significantly reduced the infarction size 3 days after stroke.CONCLUSION:
IPostC was confirmed to reduce infarction size. The effects of IPostC are definitely affected by differences in the protocol used, including the number of cycles, the duration of individual ischemia/reperfusion episode and the entire duration of the IPostC stimuli.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Suturas
/
Encéfalo
/
Reperfusão
/
Fármacos Neuroprotetores
/
Artéria Cerebral Média
/
Acidente Vascular Cerebral
/
Modelos Animais
/
Pós-Condicionamento Isquêmico
/
Infarto
/
Isquemia
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Journal of Cerebrovascular and Endovascular Neurosurgery
Ano de publicação:
2018
Tipo de documento:
Artigo