The effect of metformin on culture conversion in tuberculosis patients with diabetes mellitus
The Korean Journal of Internal Medicine
; : 933-940, 2018.
Article
em En
| WPRIM
| ID: wpr-717189
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND/AIMS:
Patients with diabetes mellitus (DM) and tuberculosis (TB) have increased morbidity and a high risk of treatment failure or recurrence. It is important to manage both diseases simultaneously. Among anti-diabetic drugs, metformin inhibits intracellular growth of mycobacteria. Therefore, we examined the effects of metformin on TB treatment, especially in patients with DM.METHODS:
This retrospective cohort study included patients with culture-positive pulmonary TB diagnosed between 2011 and 2012. The primary study outcome was sputum culture conversion after 2 months of treatment.RESULTS:
Of 499 patients diagnosed with culture-positive pulmonary TB, 105 (21%) had DM at diagnosis. Among them, 62 (59.5%) were treated with metformin. Baseline characteristics, except for the presence of chronic renal disease, were not significantly different between the metformin and non-metformin groups. Metformin treatment had no significant effect on sputum culture conversion (p = 0.60) and recurrence within 1 year after TB treatment completion (p = 0.39). However, metformin improved the sputum culture conversion rate in patients with cavitary pulmonary TB, who have higher bacterial loads (odds ratio, 10.8; 95% confidence interval, 1.22 to 95.63).CONCLUSIONS:
Among cavitary pulmonary TB patients with DM, metformin can be an effective adjunctive anti-TB agent to improve sputum culture conversion after 2 months of treatment.Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Recidiva
/
Escarro
/
Tuberculose
/
Estudos Retrospectivos
/
Estudos de Coortes
/
Falha de Tratamento
/
Diabetes Mellitus
/
Diagnóstico
/
Insuficiência Renal Crônica
/
Carga Bacteriana
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
The Korean Journal of Internal Medicine
Ano de publicação:
2018
Tipo de documento:
Article