ABO Incompatible Living Donor Liver Transplantation: A Single Center Experience / 대한이식학회지
The Journal of the Korean Society for Transplantation
; : 84-91, 2018.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-718769
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
This study examined the outcomes of ABO incompatible living donor liver transplantation (LDLT). The changes in the immunologic factors that might help predict the long term outcomes were also studied.METHODS:
Twenty-three patients, who underwent ABO incompatible LDLT from 2010 to 2015, were reviewed retrospectively. The protocol was the same as for ABO compatible LDLT except for the administration of rituximab and plasma exchange. The clinical outcomes and immunologic factors, such as isoagglutinin titer and cluster of differentiation 20+ (CD20+) lymphocyte levels were reviewed.RESULTS:
The center showed a 3-year survival of 64% with no case of antibody-mediated rejection. When transplantation-unrelated mortalities (for example, traffic accidents and myocardial infarction) were removed from statistical analysis, the 3-year survival was 77.8%. Although isoagglutinin titers continued to remain at low levels, the CD20+ lymphocyte levels recovered to the pre-Rituximab levels at postoperative one year.CONCLUSIONS:
As donor shortages continue, ABO incompatible liver transplantation is a feasible method to expand the donor pool. On the other hand, caution is still needed until more long-term outcomes are reported. Because CD20+ lymphocytes are recovered with time, more immunologic studies will be needed in the future.
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Meta 3.6: Reduzir as mortes e traumatismos por acidentes de transito
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Troca Plasmática
/
Doadores de Tecidos
/
Sistema ABO de Grupos Sanguíneos
/
Linfócitos B
/
Linfócitos
/
Acidentes de Trânsito
/
Estudos Retrospectivos
/
Mortalidade
/
Transplante de Fígado
/
Doadores Vivos
Tipo de estudo:
Guia de prática clínica
/
Estudo observacional
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
The Journal of the Korean Society for Transplantation
Ano de publicação:
2018
Tipo de documento:
Artigo