Rhabdomyosarcoma Presenting as Acute Leukemia Identified by Cytogenetic and FISH Analysis of Bone Marrow / 대한혈액학회지
Korean Journal of Hematology
; : 297-301, 2000.
Article
em Ko
| WPRIM
| ID: wpr-720341
Biblioteca responsável:
WPRO
ABSTRACT
Rhabdomyosarcoma is the most common malignant soft tissue tumor in children. In adults, however, it is extremely rare, with only a few cases observed. We describe a case of an adolescent who presented with hematologic findings compatible with acute leukemia. A 35-year-old woman was transferred to the Dong-A University Hospital for further evaluation of thrombocytopenia, anemia, and ovarian mass lesions. The peripheral blood film showed a leukoerythroblastic picture with circulating blasts. The bone marrow was markedly hypercellular and 85.6 % of all nucleated cells were atypical tumor cells. Immunophenotyping with both myeloid and lymphoid markers was all negative. With cytogenetic analysis of bone marrow 8 of 11 metaphases were characterized by a translocation t(2;13)(q35;q14), strongly indicated a diagnosis of alveolar rhabdomyosarcoma. Fluorescence in situ hybridization (FISH) using whole chromosome paints for chromosomes 2 and 13 confirmed the cytogenetic diagnosis.
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Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Pintura
/
Rabdomiossarcoma
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Trombocitopenia
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Medula Óssea
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Leucemia
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Imunofenotipagem
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Hibridização In Situ
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Rabdomiossarcoma Alveolar
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Análise Citogenética
/
Citogenética
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adolescent
/
Adult
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Child
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Female
/
Humans
Idioma:
Ko
Revista:
Korean Journal of Hematology
Ano de publicação:
2000
Tipo de documento:
Article