Remission Induction by Arsenic Trioxide in Patient with Relapsed Acute Promyelocytic Leukemia after Allogeneic Bone Marrow Transplantation / 대한혈액학회지
Korean Journal of Hematology
; : 218-222, 2002.
Article
em Ko
| WPRIM
| ID: wpr-720833
Biblioteca responsável:
WPRO
ABSTRACT
All-trans retinoic acid (ATRA) therapy induces complete remission in acute promyelocytic leukemia (APL) via differentiation of the APL cells. Recent clinical trials in China and United states showed that arsenic trioxide (ATO) is an effective and relatively safe drug in the treatment of APL. The patient was 29-year-old woman with APL who had been treated heavily with allogeneic bone marrow transplantation (BMT) in 4 years ago and reinduction chemotherapy plus donor lymphocyte infusion (DLI) after relapse in 2 years ago. After diagnosis for relapse, she had been treated with ATRA, but unfortunately failed. She was treated with ATO at the dose of 10 mg/day intravenously for 6 weeks. Complete remission was achieved at 3 weeks and the cumulative dose of ATO during induction was 420mg. She had complete remission without severe adverse effects except mild impairment of liver function and is following up for 6 months. We report a case of remission induction by ATO in ATRA refractory APL patient who experienced multiple relapse after allogeneic BMT, chemotherapy and DLI.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Arsênio
/
Recidiva
/
Doadores de Tecidos
/
Tretinoína
/
Estados Unidos
/
Medula Óssea
/
Indução de Remissão
/
Linfócitos
/
Leucemia Promielocítica Aguda
/
China
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Female
/
Humans
País/Região como assunto:
America do norte
/
Asia
Idioma:
Ko
Revista:
Korean Journal of Hematology
Ano de publicação:
2002
Tipo de documento:
Article