Evaluation of the Effect of Initial dose of Vancomycin using Serum Cystatin C as a Marker in Elderly Patients / 감염과화학요법
Infection and Chemotherapy
; : 224-229, 2009.
Article
em Ko
| WPRIM
| ID: wpr-722113
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: It has been suggested that the glomerular filtration rate can be predicted on the basis of serum cystatin C concentration. The aim of this study was to investigate the clinical utility of serum cystatin C as a marker of renal function and to evaluate the effect of an initial dose of vancomycin using serum cystatin C concentration in elderly patients. MATERIALS AND METHODS: Data was collected from July 2006 to September 2008. The subjects were elderly patients (> or =60-years-of-age; n=number of patients) who had been treated with vancomycin. Serum concentrations of parameters including vancomycin, creatinine, and cystatin C were measured. Correlations between measured vancomycin concentrations and predicted vancomycin concentrations based on serum cystatin C or serum creatinine were compared, and the initial dose setting of vancomycin on the basis of serum cystatin C concentration was evaluated. RESULTS: Serum cystatin C was a good marker of renal function in comparison with serum creatinine for various doses of vancomycin in the elderly subject. In subpopulation (n=88) with normal serum cystatin C level (< or =1.2 mg/L) who were treated with routine adult vancomycin dose (1g q 12 hours), vancomycin concentration was within the therapeutic range (5-15 mg/L) in 68 patients (77.3%), and was <20 mg/L in 77 of the 88 patients (88.5 %). CONCLUSIONS: Predictive prowess of serum vancomycin concentrations on the basis of the serum cystatin C concentration could be better than that based on the serum creatinine concentration in elderly patients.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Vancomicina
/
Monitoramento de Medicamentos
/
Creatinina
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Cistatina C
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Taxa de Filtração Glomerular
Limite:
Adult
/
Aged
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Humans
Idioma:
Ko
Revista:
Infection and Chemotherapy
Ano de publicação:
2009
Tipo de documento:
Article