A Prospective Study on an Association between Apolipoprotein E epsilon4 and Cognitive Change in Community-Dwelling Elders with Alzheimer's Disease
Journal of the Korean Society of Biological Psychiatry
; : 104-110, 2013.
Article
em Ko
| WPRIM
| ID: wpr-725010
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVES: The aim of this study was to examine the prospective impact of the apolipoprotein E (APOE) epsilon4 on cognitive performance in the community-dwelling elderly individuals with Alzheimer's disease (AD). METHODS: The total number of subjects was 30 (12 men and 18 women) who were diagnosed with AD from a Korean project of "Early Detection of Dementia". People aged 65-85 years were included in the analysis. The eight neuropsychological domains from the Korean version of Consortium to Establish a Registry of Alzheimer's Disease (CERAD-K) were conducted to test subjects. They have been followed at 24-month intervals with the same assessments at each interval. Their cognitive performance at 2 year intervals was compared by the occurrence of the APOE epsilon4. RESULTS: The impact of epsilon4 allele was significant in the Word List Memory Test (WLMT, F = 4.345, df = 1, p = 0.021) and Word List Recall Test (WLRT, F = 5.569, df = 1, p = 0.033). CONCLUSIONS: The APOE epsilon4 allele was significantly correlated especially with verbal episodic memory domain in community-dwelling elders diagnosed with AD.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Apolipoproteínas
/
Apolipoproteínas E
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Estudos Prospectivos
/
Alelos
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Doença de Alzheimer
/
Memória Episódica
/
Memória
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Aged
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Humans
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Male
Idioma:
Ko
Revista:
Journal of the Korean Society of Biological Psychiatry
Ano de publicação:
2013
Tipo de documento:
Article