Regulation of DREAM Expression by Group I mGluR
The Korean Journal of Physiology and Pharmacology
; : 95-100, 2011.
Article
em En
| WPRIM
| ID: wpr-727372
Biblioteca responsável:
WPRO
ABSTRACT
DREAM (downstream regulatory element antagonistic modulator) is a calcium-binding protein that regulates dynorphin expression, promotes potassium channel surface expression, and enhances presenilin processing in an expression level-dependent manner. However, no molecular mechanism has yet explained how protein levels of DREAM are regulated. Here we identified group I mGluR (mGluR1/5) as a positive regulator of DREAM protein expression. Overexpression of mGluR1/5 increased the cellular level of DREAM. Up-regulation of DREAM resulted in increased DREAM protein in both the nucleus and cytoplasm, where the protein acts as a transcriptional repressor and a modulator of its interacting proteins, respectively. DHPG (3,5-dihydroxyphenylglycine), a group I mGluR agonist, also up-regulated DREAM expression in cortical neurons. These results suggest that group I mGluR is the first identified receptor that may regulate DREAM activity in neurons.
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Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Dinorfinas
/
Canais de Potássio
/
Proteínas
/
Regulação para Cima
/
Cálcio
/
Receptores de Glutamato Metabotrópico
/
Citoplasma
/
Presenilinas
/
Metoxi-Hidroxifenilglicol
/
Neurônios
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
The Korean Journal of Physiology and Pharmacology
Ano de publicação:
2011
Tipo de documento:
Article