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Effect of Diazepam on the Contents of Amino Acids and Free Radical during Ischemia/Reperfusion Injury / 华中科技大学学报(医学)(英德文版)
Article em Zh | WPRIM | ID: wpr-735692
Biblioteca responsável: WPRO
ABSTRACT
The protective effect and mechanism of diazepam on ischemia neurons during cerebral ischemia and reperfusion were studied. Sixty-three Wistar rats were divided randomly into nine groups control group (n=7), ischemia (is) groups including subgroups of is3h, is3-h/rep1-h, is3-h/rep2-h, is3-h/rep3-h(n=7 in each group), diazepam treated groups (10 mg/kg, i.p.), including subgroups of is3-h, is3-h/rep1-h, is3-h/rep2-h, is3-h/rep3-h (n=7 in each group) with Zea longa's animal model of middle cerebral artery occlusion. The comparison between the ischemia group and diazepam-treated group showed that diazepam could obviously decrease the production of glutamate, asparate, MDA and increase the synthesis and release of GABA, SOD and GSH-PX. It was concluded that diazepam exerted its protective effects on neurons through complex mechanisms of regulating the synthesis and release of excitotary/inhibitory amino acids and free radicals.
Texto completo: 1 Base de dados: WPRIM Idioma: Zh Revista: Journal of Huazhong University of Science and Technology (Medical Sciences) Ano de publicação: 2001 Tipo de documento: Article
Texto completo: 1 Base de dados: WPRIM Idioma: Zh Revista: Journal of Huazhong University of Science and Technology (Medical Sciences) Ano de publicação: 2001 Tipo de documento: Article
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