A Case of Infantile Nephrotic Syndrome associated with Neuroblastoma
Childhood Kidney Diseases
; : 91-96, 2018.
Article
em En
| WPRIM
| ID: wpr-739191
Biblioteca responsável:
WPRO
ABSTRACT
Nephrotic syndrome in the first year of life, characterized by renal dysfunction and proteinuria, is associated with a heterogeneous group of disorders. These disorders are often related to genetic mutations, but the syndrome can also be caused by a variety of other diseases. We report an infant with nephrotic syndrome associated with a neuroblastoma. A 6-month-old girl was admitted with a 10% weight loss over 10 days and nephrotic-range proteinuria. She was ill-looking, and her blood pressure was higher than normal for her age. Her cystatin-C glomerular filtration rate was decreased, and levels of plasma renin, aldosterone, and catecholamines were elevated. Renal ultrasonography and abdominal computed tomography showed a retroperitoneal prevertebral mass encasing both renal arteries and the left renal vein. The mass was partially resected laparoscopically, and the pathologic diagnosis was neuroblastoma. Findings on a simultaneous renal biopsy were unremarkable. The patient was treated with chemotherapy and several anti-hypertensive drugs, including an alpha blocker. Two months later, the mass had decreased in size and the proteinuria and hypertension were gradually improving. In an infant with abnormal renin-angiotensin system activation, severe hypertension, and nephrotic-range proteinuria, neuroblastoma can be considered in the differential diagnosis.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Plasma
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Proteinúria
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Artéria Renal
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Veias Renais
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Sistema Renina-Angiotensina
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Biópsia
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Pressão Sanguínea
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Redução de Peso
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Catecolaminas
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Ultrassonografia
Tipo de estudo:
Diagnostic_studies
Limite:
Female
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Humans
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Infant
Idioma:
En
Revista:
Childhood Kidney Diseases
Ano de publicação:
2018
Tipo de documento:
Article