Effect of Eptazocine Hydrobromide on Emergence Agitation of Patients Undergoing Video-assisted Thoracoscopic Surgery / 医药导报

ABSTRACT

Objective To investigate the effect of eptazocine hydrobromide on emergence agitation (EA) of patients undergoing video-assisted thoracoscopic surgery at recovery period. Methods One hundred and twenty patients with ASA I or II,scheduled to undergo video-assisted thoracoscopic surgery vats under general anesthesia, were randomly allocated to three groups(n = 40) eptazocine hydrobromide injection group (group E) , dezocine injection group (group D) and sodium chloride injection group (group NS) . Eptazocine hydrobromide injection 0. 3 mg· kg-1, dezocine injection 0. 1 mg· kg-1 and sodium chloride injectionin equal volume were administrated to group E, group D and group NS, respectively, 15 min before the termination of surgery. The operation time,awakening time,extubation time and postanesthesia care unit (PACU) staying time of all patients were recorded. Riker sedation-agitation scores, MAP and HR were documented at the time of awakening (t0) and 10 min (t1) ,20 min (t2) and 30 min (t3) after awakening,and the incidence of EA was also recorded. Results There were no significant differences in operation time,awakening time, extubation time, PACU staying time among three groups(P>0.05) . Compared with the group NS,the riker sedation-agitation scores and MAP in group E and D at t0– t3 were lower, as well as the incidence of EA. HR of group E was lower at t1– t3,while HR of group D was lower at t2 and t3(P<0.05) . Compared with group D,riker sedation-agitation scores and MAPs in group E were lower at t1 and t2, while HR was lower at t2(P<0.05) . However, there was no difference in incidence of EA between group D and group E (P>0.05) . Conclusion Administration 0.3 mg· kg-1 eptazocine hydrobromide,15 min before the termination of surgery, could effectively reduce the incidence of EA in patients undergoing video-assisted thoracoscopic surgery after general anesthesia. Simultaneously, awakening time, extubation time and PACU staying time could not prolonged.