Risks and predictors of mortality among human immunodeficiency virus-infected children receiving highly active antiretroviral therapy in Yunnan Province / 中华传染病杂志
Chinese Journal of Infectious Diseases
; (12): 28-31, 2019.
Article
em Zh
| WPRIM
| ID: wpr-745012
Biblioteca responsável:
WPRO
ABSTRACT
Objective To investigate the influence factors of mortality among human immunodeficiency virus (HIV)-infected children under highly active antiretroviral therapy (HAART).Methods Retrospective cohort study of 652 children initiated HAART from 2005 to 2014 was conducted,and enrolled patients were followed-up until December,2015.Survival data was analyzed using Kaplan-Meier method and Cox regression model was used to identify independent predictors of mortality among these children on HARRT.Chi-square test and Fisher's exact test were used for comparison between groups.Results Overall,26 of the children died over a follow-up period of 3 116.24 child-years,with a mortality rate of 0.83 per 100 child-years.Twelve (46%)of deaths occurred during the first six months after starting HAART.Cox regression analysis of variables showed that the World Health Organization (WHO) clinical stages Ⅲ/Ⅳ (hazard rate [HR] =10.717,95%confidence interal [95% CI]:4.189-4.749,P =0.000),baseline hemoglobin < 80 g/L (HR =14.768,95 % CI:5.721-38.125,P =0.000),tuberculosis co-infection (HR =4.794,95% CI:2.105-10.918,P =0.000),baseline CD4+T lymphocyte < 50 cells/μL (HR =4.219,95% CI:1.524-11.680,P =0.006),weight-for-age z-score <-2 (HR =2.983,95 % CI:1.094-8.135,P =0.033) were independently associated with death,whereas the age < 7 year-old at HAART initiation was protectire (HR =0.293,95% CI:0.126-0.684,P =0.005).Conclusions The mortality of children receiving HAART is strongly associated with WHO stages Ⅲ/Ⅳ,hemoglobin < 80 g/L,weight-for-age z-score <-2,tuberculosis co-infection and older age at treatment.
Texto completo:
1
Base de dados:
WPRIM
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
Idioma:
Zh
Revista:
Chinese Journal of Infectious Diseases
Ano de publicação:
2019
Tipo de documento:
Article