Up-regulation of MUC2 mucin gene in chronic rhinosinusitis / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
; (24): 486-488, 2007.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-748390
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the expression of MUC2 in human sinus mucosa and compare the expression of MUC2 mRNAs in normal and in chronic sinus mucosa.@*METHOD@#Thirty-two chronic ethmoid sinusitis mucosa samples and 8 normal ethmoid sinus mucosa samples were obtained; RNAs were extracted from sinus mucosa, and fluorescent quantitative PCR was performed for MUC2.@*RESULT@#The levels of MUC2 mRNAs in chronic rhinosinusitis were significantly increased compared with those in normal sinus mucosa.@*CONCLUSION@#This result suggest that up-regulation of MUC2 in chronic rhinosinusitis may play an important role in the pathogenesis of sinus hypersecretion in chronic rhinosinusitis.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sinusite
/
Estudos de Casos e Controles
/
Regulação para Cima
/
Mucina-2
/
Genética
/
Metabolismo
/
Mucosa Nasal
Tipo de estudo:
Estudo observacional
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Ano de publicação:
2007
Tipo de documento:
Artigo