An Application of Norepinephrine in Renal Transplantation Guided by Hemodynamic Monitoring / 昆明医科大学学报

ABSTRACT

Objective To investigate the use of noradrenaline under different monitoring methods in renal transplantation and its clinical significance in prognosis. Methods 40 patients under the surgery of renal allograft were randomly divided into two groups (20 patients each) Flotrac-vigileo group (E) and the standard monitoring group (N), then we recorded MAP (mean arterial pressure), CVP (central venous pressure) and HR (heart rate) value divided by 5 periods after induction of general anesthesia (T1), before operation (T2), external iliac vein occlusion (T3), external iliac vein opening (T4) and the end of operation (T5).Meanwhile, intraoperative norepinephrine dosage, intake and output volumnand renal function indicators during postoperative and after three days were also studies. Length of hospital stay were also compared in this essay.Results The amount of norepinephrine in group E during operation was significantly lower than that in group N (P＜0.05). The urine volume in group E during operation was significantly higher than that in group N (P＜0.05). There was no significant difference between the two groups in the amount of transfusion, blood loss and the indexes of kidney function. Conclusions Hemodynamics monitored by peripheral cardiac output significantly reduced the amount of norepinephrine used in renal transplantation, also in the risk of renal damage. Yet it increased the amount of intraoperative urine output, which provided more accurate and personalized management of intraoperative vasoactive drugs.