Real-world Treatment Pattern and Outcomes of Hypercalcemia among Solid Tumor Patients
Korean Journal of Clinical Pharmacy
; : 166-172, 2019.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-759626
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
Hypercalcemia is an important metabolic emergency condition in cancer patients. Bisphosphonate is the treatment of choice for hypercalcemia, whereas calcitonin and hydration with furosemide are recommended for acute supportive therapy. However, data regarding real-world treatment patterns and outcomes of pharmacological treatments are limited. Therefore, we aimed to investigate the treatment patterns and clinical outcomes of hypercalcemia treatment in solid tumor patients.METHODS:
Electronic medical records of 123 adults with solid cancers and albumin-corrected calcium levels >10.5 mg/dL or ionized calcium levels >1.35 mmol/L were reviewed. We retrospectively analyzed the pharmacological treatment and recovery rate according to the severity of hypercalcemia.RESULTS:
A total of 177 cases were identified, of which 49 were not treated and 30 were treated with hydration only. In moderate-to-severe cases, 86.5% received pharmacological treatment. Thirty-four cases (19.2%) were treated with bisphosphonate alone and 58 cases (32.8%) were treated with bisphosphonate and calcitonin. In mild hypercalcemia cases, the recovery rate was higher for those receiving hydration only or pharmacological treatment (79.7%) than for those receiving no treatment (61.4%, p = 0.041). Most moderate-to-severe cases were treated with medication and of those treated, 56.3% recovered. The recovery rate was lower in those treated with bisphosphonate alone (38.2%) than in those who underwent calcitonin combination treatment (73.7%, p = 0.001).CONCLUSIONS:
Bisphosphonate combined with calcitonin was found to be more effective than bisphosphonate alone for the treatment of moderate-to-severe hypercalcemia. Considering the current shortage of calcitonin, further efforts are required to ensure its stable supply.
Texto completo:
Disponível
Contexto em Saúde:
Agenda de Saúde Sustentável para as Américas
Problema de saúde:
Objetivo 6: Sistemas de informação em saúde
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Calcitonina
/
Cálcio
/
Estudos Retrospectivos
/
Emergências
/
Registros Eletrônicos de Saúde
/
Furosemida
/
Hipercalcemia
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Adulto
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Clinical Pharmacy
Ano de publicação:
2019
Tipo de documento:
Artigo