BioPATH: A Biomarker Study in Asian Patients with HER2+ Advanced Breast Cancer Treated with Lapatinib and Other Anti-HER2 Therapy / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
; : 1527-1539, 2019.
Article
em En
| WPRIM
| ID: wpr-763208
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
BioPATH is a non-interventional study evaluating the relationship of molecular biomarkers (PTEN deletion/downregulation, PIK3CA mutation, truncated HER2 receptor [p95HER2], and tumor HER2 mRNA levels) to treatment responses in Asian patients with HER2+ advanced breast cancer treated with lapatinib and other HER2-targeted agents. MATERIALS ANDMETHODS:
Female Asian HER2+ breast cancer patients (n=154) who were candidates for lapatinib-based treatment following metastasis and having an available primary tumor biopsy specimen were included. The primary endpoint was progression-free survival (PFS). Secondary endpoints were response rate, overall survival on lapatinib, correlation between biomarker status and PFS for any previous trastuzumab-based treatment, and conversion/conservation rates of the biomarker status between tissue samples collected at primary diagnosis and at recurrence/metastasis. Potential relationships between tumor mRNA levels of HER2 and response to lapatinib-based therapy were also explored.RESULTS:
p95HER2, PTEN deletion/downregulation, and PIK3CA mutation did not demonstrate any significant co-occurrence pattern and were not predictive of clinical outcomes on either lapatinib-based treatment or any previous trastuzumab-based therapy in the metastatic setting. Proportions of tumors positive for p95HER2 expression, PIK3CA mutation, and PTEN deletion/down-regulation at primary diagnosis were 32%, 31.2%, and 56.2%, respectively. Despite limited availability of paired samples, biomarker status patterns were conserved in most samples. HER2 mRNA levels were not predictive of PFS on lapatinib.CONCLUSION:
The prevalence of p95HER2 expression, PIK3CA mutation, and PTEN deletion/downregulation at primary diagnosis were similar to previous reports. Importantly, no difference was observed in clinical outcome based on the status of these biomarkers, consistent with reports from other studies.Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Biópsia
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Mama
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Neoplasias da Mama
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RNA Mensageiro
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Biomarcadores
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Prevalência
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Intervalo Livre de Doença
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Povo Asiático
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Diagnóstico
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Trastuzumab
Tipo de estudo:
Diagnostic_studies
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Prevalence_studies
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Prognostic_studies
Limite:
Female
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Humans
Idioma:
En
Revista:
Cancer Research and Treatment
Ano de publicação:
2019
Tipo de documento:
Article