The Role of Autoantibodies in Idiopathic Inflammatory Myopathies
Journal of Rheumatic Diseases
; : 165-178, 2019.
Article
em En
| WPRIM
| ID: wpr-766185
Biblioteca responsável:
WPRO
ABSTRACT
Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of autoimmune muscle diseases with systemic involvement. Patients with IIM present with varying degrees of muscle disease, cutaneous manifestations, and internal organ involvement. The diagnosis and classification of IIM is based primarily on the classification system composed of clinical features, laboratory value and muscle biopsy. In addition, the identification and characterization of myositis-related autoantibodies can help diagnosis and classification. Recently, many studies have also demonstrated that the physician can define the clinical syndromes, establish treatment strategy and predict outcomes based on the patients' myositis-specific autoantibodies (MSA) and myositis-associated antibodies (MAA) profiles. MSAs are found exclusively in IIMs and facilitate the identification of subsets of patients with relatively homogeneous clinical features. MAAs are frequently found in association with other MSA; however, they may also be detected in various connective diseases.
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Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Autoanticorpos
/
Biópsia
/
Anticorpos Antinucleares
/
Classificação
/
Polimiosite
/
Dermatomiosite
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Diagnóstico
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Anticorpos
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Miosite
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Journal of Rheumatic Diseases
Ano de publicação:
2019
Tipo de documento:
Article