Deubiquitinases as pivotal regulators of T cell functions / 医学前沿
Frontiers of Medicine
; (4): 451-462, 2018.
Article
em En
| WPRIM
| ID: wpr-771296
Biblioteca responsável:
WPRO
ABSTRACT
T cells efficiently respond to foreign antigens to mediate immune responses against infections but are tolerant to self-tissues. Defect in T cell activation is associated with severe immune deficiencies, whereas aberrant T cell activation contributes to the pathogenesis of diverse autoimmune and inflammatory diseases. An emerging mechanism that regulates T cell activation and tolerance is ubiquitination, a reversible process of protein modification that is counter-regulated by ubiquitinating enzymes and deubiquitinases (DUBs). DUBs are isopeptidases that cleave polyubiquitin chains and remove ubiquitin from target proteins, thereby controlling the magnitude and duration of ubiquitin signaling. It is now well recognized that DUBs are crucial regulators of T cell responses and serve as potential therapeutic targets for manipulating immune responses in the treatment of immunological disorders and cancer. This review will discuss the recent progresses regarding the functions of DUBs in T cells.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Patologia
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Fisiologia
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Linfócitos T
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Transdução de Sinais
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Diferenciação Celular
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Tratamento Farmacológico
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Ubiquitinação
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Descoberta de Drogas
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Enzimas Desubiquitinantes
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Metabolismo
Limite:
Humans
Idioma:
En
Revista:
Frontiers of Medicine
Ano de publicação:
2018
Tipo de documento:
Article