Flavonoids with PTP1B inhibition from Broussonetia papyrifera / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 88-94, 2019.
Article
em Zh
| WPRIM
| ID: wpr-771513
Biblioteca responsável:
WPRO
ABSTRACT
Eleven flavonoids were isolated from the twigs of Broussonetia papyrifera by column chromatography over silica gel,ODS,MCI gel,and Sephadex LH-20,as well as RP-HPLC.Their structures were identified by spectroscopic methods including NMR,MS,UV,and IR as broupapyrin A(1),5,7,3',4'-tetrahydroxy-3-methoxy-8-geranylflavone(2),8-prenylquercetin-3-methyl ether(3),broussonol D(4),broussoflavonol B(5),uralenol(6),broussonol E(7),8-(1,1-dimethylallyl)-5'-(3-methylbut-2-enyl)-3',4',5,7-tetrahydroxyflanvonol(8),broussoflavonol E(9),4,2',4'-trihydroxychalcone(10),and butein(11).Compound 1 is a new isoprenylated flavonol.Compounds 3,6,10,and 11 were obtained from the genus Broussonetia for the first time,and 4 and 7 were firstly discovered in B.papyrifera.Compounds 1-5 and 7-9 showed significant inhibitory effects on PTP1 B with IC50 values ranging from(0.83±0.30) to(4.66±0.83) μmol·L-1.
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Base de dados:
WPRIM
Assunto principal:
Farmacologia
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Flavonoides
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Espectroscopia de Ressonância Magnética
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Química
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Cromatografia Líquida de Alta Pressão
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Broussonetia
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Proteína Tirosina Fosfatase não Receptora Tipo 1
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Compostos Fitoquímicos
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2019
Tipo de documento:
Article