Preparation and evaluation of carboxymethyl chitosan/sodium alginate hydrogel for cartilage tissue engineering / 华西口腔医学杂志
West China Journal of Stomatology
; (6): 253-259, 2019.
Article
em Zh
| WPRIM
| ID: wpr-772666
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#This study aimed to optimize the preparation of carboxymethyl chitosan/sodium alginate (CMCS/OSA) compound hydrogels. This study also aimed to investigate the applicability of the hydrogels in cartilage tissue engi-neering.@*METHODS@#Three groups of CMCS/OSA composite hydrogels with amino-to-aldehyde ratios of 2∶1, 1∶1 and 1∶2 were prepared. The microstructure, physical properties, and cell biocompatibility of the three groups of CMCS/OSA com-posite hydrogels were evaluated. Samples were subjected to scanning electron microscopy, rheological test, adhesion tension test, swelling rate test, and cell experiments to identify the CMCS/OSA composite hydrogel with the cross-linking degree that can meet the requirements for scaffolds in cartilage tissue engineering.@*RESULTS@#The experimental results showed that the CMCS/OSA hydrogel with a amine-to-aldhyde ratio of 1∶1 had good porosity, suitable gelling time, strong adhesive force, stable swelling rate, and good cellular biocompatibility.@*CONCLUSIONS@#The CMCS/OSA compound hydrogel prepared with a 1∶1 ratio of amino and aldehyde groups has potential applications in cartilage tissue engineering.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Cartilagem
/
Hidrogéis
/
Engenharia Tecidual
/
Quitosana
/
Alginatos
Idioma:
Zh
Revista:
West China Journal of Stomatology
Ano de publicação:
2019
Tipo de documento:
Article