Altered Neuronal Activity in the Central Nucleus of the Amygdala Induced by Restraint Water-Immersion Stress in Rats / 神经科学通报·英文版
Neuroscience Bulletin
; (6): 1067-1076, 2018.
Article
em En
| WPRIM
| ID: wpr-775483
Biblioteca responsável:
WPRO
ABSTRACT
Restraint water-immersion stress (RWIS), a compound stress model, has been widely used to induce acute gastric ulceration in rats. A wealth of evidence suggests that the central nucleus of the amygdala (CEA) is a focal region for mediating the biological response to stress. Different stressors induce distinct alterations of neuronal activity in the CEA; however, few studies have reported the characteristics of CEA neuronal activity induced by RWIS. Therefore, we explored this issue using immunohistochemistry and in vivo extracellular single-unit recording. Our results showed that RWIS and restraint stress (RS) differentially changed the c-Fos expression and firing properties of neurons in the medial CEA. In addition, RWIS, but not RS, induced the activation of corticotropin-releasing hormone neurons in the CEA. These findings suggested that specific neuronal activation in the CEA is involved in the formation of RWIS-induced gastric ulcers. This study also provides a possible theoretical explanation for the different gastric dysfunctions induced by different stressors.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Patologia
/
Fisiologia
/
Estresse Fisiológico
/
Estresse Psicológico
/
Potenciais de Ação
/
Hormônio Liberador da Corticotropina
/
Regulação da Expressão Gênica
/
Análise de Variância
/
Proteínas Proto-Oncogênicas c-fos
/
Ratos Wistar
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Neuroscience Bulletin
Ano de publicação:
2018
Tipo de documento:
Article