Role of inflammatory factors in development and progression of alcoholic liver disease / 临床肝胆病杂志

ABSTRACT

Alcohol liver disease (ALD) is the most common disease resulting in liver injury in the world. Inflammatory response is an important reason for liver injury in ALD. After being absorbed into the intestines, alcohol can increase the amount of intestinal endotoxin which enters the bloodstream through enterohepatic circulation and activates Toll-like receptor 4 in liver Kupffer cells to release inflammatory factors. The inflammatory factors including tumor necrosis factor-α induce liver injury, while interleukin-6 (IL-6) and interleukin-10 (IL-10) protect the liver through regulating inflammatory response. IL-6 can increase the expression of various anti-injury genes in hepatocytes through activating signal transducer and activator of transcription 3 (STAT3), and IL-10 can inhibit liver inflammatory response through activating STAT3 in Kupffer cells. The processes of imbalance and rebalance between proinflammatory factors and anti-inflammatory factors are the development and prognosis of ALD. This article systematically reviews the role of inflammatory factors in the development and progression of ALD from the perspective of inflammatory response.