Influencing factors for hepatic venous pressure gradient in patients with cirrhotic portal hypertension / 临床肝胆病杂志

ABSTRACT

ObjectiveTo investigate the influencing factors for hepatic venous pressure gradient (HVPG) in patients with cirrhotic portal hypertension undergoing transjugular intrahepatic portosystemic shunt (TIPS). MethodsA total of 158 patients with cirrhotic portal hypertension who underwent TIPS in The General Hospital of Western Theater Command of the Chinese PLA from January 2015 to December 2018 were enrolled. Wedged hepatic venous pressure (WHVP), free hepatic venous pressure (FHVP), and portal venous pressure (PVP) were measured during TIPS, and HVPG and portal venous pressure gradient (PVPG) were calculated. The t-test was used for comparison of continuous data between two groups; a one-way analysis of variance was used for comparison between multiple groups, and the least significant difference t-test was used for further comparison between two groups. The Pearson correlation coefficient was used to analyze the correlation between HVPG and PVPG, and a multivariate linear stepwise regression analysis was used to investigate the independent risk factors for HVPG. ResultsHVPG was positively correlated with PVPG (r=0.796, P＜0.001). The one-way analysis of variance showed that age and etiology were influencing factors for HVPG (F=19.900 and 10.287, both P＜0.001). The multivariate linear stepwise regression analysis showed that age and etiology were independent influencing factors for HVPG (t=7.870 and -2.178, both P＜0.001). ConclusionAge and etiology are independent influencing factors for HVPG in patients with cirrhotic portal hypertension, and the patients aged ≥60 years or the patients with hepatitis C virus-related cirrhosis tend to have higher HVPG.