Advances in study of macrophages in chemotherapy resistance of cancer / 药学学报
Acta Pharmaceutica Sinica
; (12): 1513-2016.
Article
em Zh
| WPRIM
| ID: wpr-779319
Biblioteca responsável:
WPRO
ABSTRACT
As extremely important inflammatory cells in the tumor microenvironment, tumor-associated macrophages (TAMs) can secrete a variety of chemokines and cytokines, which play an important role in the occurrence of tumor growth and metastasis. Recent years, increasing studies have shown that macrophages are associated with tumor chemotherapy sensitivity. The chemical substances produced by macrophages affect the efficacy of chemotherapeutic agents. In addition, some chemotherapeutic agents have an effect on the recruitment and bioactivity of macrophages in the tumor issue, which influences the anti-tumor efficacy of chemotherapy drugs. In this review, we summarize the roles of macrophages in the chemotherapy resistance, including the regulatory mechanism and the strategy of targeting macrophages.
Texto completo:
1
Base de dados:
WPRIM
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2016
Tipo de documento:
Article