Exploring Genetic Susceptibility to Fibromyalgia / 전남의대학술지
Chonnam Medical Journal
; : 58-65, 2015.
Article
em En
| WPRIM
| ID: wpr-788315
Biblioteca responsável:
WPRO
ABSTRACT
Fibromyalgia (FM) affects 1% to 5% of the population, and approximately 90% of the affected individuals are women. FM patients experience impaired quality of life and the disorder places a considerable economic burden on the medical care system. With the recognition of FM as a major health problem, many recent studies have evaluated the pathophysiology of FM. Although the etiology of FM remains unknown, it is thought to involve some combination of genetic susceptibility and environmental exposure that triggers further alterations in gene expression. Because FM shows marked familial aggregation, most previous research has focused on genetic predisposition to FM and has revealed associations between genetic factors and the development of FM, including specific gene polymorphisms involved in the serotonergic, dopaminergic, and catecholaminergic pathways. The aim of this review was to discuss the current evidence regarding genetic factors that may play a role in the development and symptom severity of FM.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Polimorfismo Genético
/
Qualidade de Vida
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Fibromialgia
/
Expressão Gênica
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Predisposição Genética para Doença
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Exposição Ambiental
Aspecto:
Patient_preference
Limite:
Female
/
Humans
Idioma:
En
Revista:
Chonnam Medical Journal
Ano de publicação:
2015
Tipo de documento:
Article