Study on receptor gene polymorphism and detection method of vitamin D / 药学实践杂志
Journal of Pharmaceutical Practice
; (6): 329-331,392, 2014.
Article
em Zh
| WPRIM
| ID: wpr-790352
Biblioteca responsável:
WPRO
ABSTRACT
In recent years , many studies have found that vitamin D insufficiency is associated with osteomalacia , hyperten-sion, diabetes, metabolic syndrome and other diseases .Vitamin D must be hydroxylated in the liver by a 25-hydroxylase for the first time, and then in the kidney by a 1α-hydroxylase for the second time to form the active metabolite 1,25-dihydroxy vitamin D ,which binds to the intracellular vitamin D receptor and exerts its effects .This paper reviewed the relationship between vitamin D and disease , present research situation of gene polymorphism of vitamin D receptor , and the advantages and limitations of several methods of vitamin D detection, and proposed the best method for detecting vitamin D receptor gene polymorphism and the importance of the detection state to guide clinicians to use drug rationally .
Texto completo:
1
Base de dados:
WPRIM
Tipo de estudo:
Diagnostic_studies
Idioma:
Zh
Revista:
Journal of Pharmaceutical Practice
Ano de publicação:
2014
Tipo de documento:
Article