Advances on the research of the pharmacological activity mechanism and toxicolo-gy of Glaucocalyxin A / 药学实践杂志
Journal of Pharmaceutical Practice
; (6): 124-128, 2016.
Article
em Zh
| WPRIM
| ID: wpr-790574
Biblioteca responsável:
WPRO
ABSTRACT
Glaucocalyxin A (GLA) is a kind of diterpenoid enantiomers with organic chemical structure of en-15-oxo-16-kaurene.It has various pharmacological activities,such as cardiovascular and endothelium cellular protection,anti-blood coagu-lation,anti-Hepatitis B Virus (HBV),anti-tumor,anti-bacteria,anti-inflammation,hypoxic tolerance,immunomodulation and Ca2+ concentration regulation effect,where as its in vivo safety is quite good.As a folk medicine,it is conventionally used to treat hepatitis,gastritis,mastitis,stomachache and arthralgia.It is also used for ischemic and/or hypoxic cardio-cerebrovas-cular diseases such as coronary heart diseases,stenocardia and chronic cerebral circulation insufficiency in clinic.This review gives a summary of the pharmacological effects,biological mechanism,and toxicity of Glaucocalyxin A.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Journal of Pharmaceutical Practice
Ano de publicação:
2016
Tipo de documento:
Article