Comparison Between Paclitaxel-Carboplatin and Paclitaxel-Cisplatin as a Combination Chemotherapy in Recurrent Ovarian Cancer / 대한부인종양콜포스코피학회잡지
Korean Journal of Gynecologic Oncology and Colposcopy
; : 120-127, 2001.
Article
em Ko
| WPRIM
| ID: wpr-80992
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
To evaluate the efficacy and side effects of cispaltin and carboplatin each in combination with paclitaxel in recurrent epithelial ovarian cancer who had not taken paclitaxel-based chemotherapy. MATERIALS ANDMETHODS:
Between January 1994 and October 1999, in department of obstetrics and gynecology, Asan medical Center, 42 recurrent ovarian cancer patients who had initial platinum-based chemotherapy except paclitaxel were treated with paclitaxel-based chemotherapy. One group was 14 patients treated with paclitaxel-cisplatin and the other group was 28 patients treated with paclitaxel-carboplatin. Disease free interval before recurrence was 6 months at least. Patients received paclitaxel 135mg/m2 followed by either cisplatin 75mg/m2 or carboplatin 300mg/m2. The schedule was repeated every 3 weeks for at least 6 cycle. Response was evaluated by physical examination, serial serum CA 125 measurement, chest PA before each cycle, and abdomino-pelvic CT scan every 3 cycles.RESULTS:
As paclitaxel-cisplaitin group, with a median follow-up of 34.5 months (range, 9-60 months), 1 patient had complete response, 6 patients had partial response, 3 patients had stable disease and 4 patients had persistent disease, overall response rate was 50%, mean survival duration was 40 months. As paclitaxel-carboplatin group, with a median follow-up of 25.5 months (7-36 months), 4 patients had complete response, 11 patients had partial response, 6 patients had stable disease, and 7 patients had persistent disease, overall response rate was 53.4%, mean survival of 24 months. As grade of side effects in each group, we evaluated leukopenia, anemia, thrombocytopenia, nausea, vomiting, fever, neurological abnormality, and renal abnormality. The rate of grade 3 to 4 leukopenia was 11% in paclitaxel-cisplatin arm and 17% paclitaxel-arboplatin, in arm.CONCLUSION:
These results demonstrate that the combined chemotherapy of paclitaxel followed by cisplatin or carboplatin is highly effective and safe in recurrent epithelial ovarian cancer who had taken no previous paclitaxel-based chemotherapy.Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Neoplasias Ovarianas
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Agendamento de Consultas
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Exame Físico
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Braço
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Recidiva
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Tórax
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Trombocitopenia
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Vômito
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Tomografia Computadorizada por Raios X
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Seguimentos
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
Ko
Revista:
Korean Journal of Gynecologic Oncology and Colposcopy
Ano de publicação:
2001
Tipo de documento:
Article