Advances in BET bromodomain protein inhibitors / 中国药科大学学报
Journal of China Pharmaceutical University
; (6): 264-271, 2015.
Article
em Zh
| WPRIM
| ID: wpr-811944
Biblioteca responsável:
WPRO
ABSTRACT
@#Recognizing acetyl-lysine of histone is a key process of epigenetic regulation that is mediated by a protein module called bromodomain(BRD). The bromodomain inhibitors of the bromodomains and extra-terminal(BET)family have shown great potential in anti-inflammatory and antiproliferative effects. Through a review of diseases and structures about BET bromodomain, different kinds of inhibitors were analyzed and their structure-activity relationships were summarized. Herenin, the recent advances reported are reviewed for discovering more excellent small molecule inhibitors.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Journal of China Pharmaceutical University
Ano de publicação:
2015
Tipo de documento:
Article