Advanced progress in classic genomic and non-genomic regulating mechanism mediated by retinoic acids in anti-cancer treatments / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 81-86, 2019.
Article
em Zh
| WPRIM
| ID: wpr-813317
Biblioteca responsável:
WPRO
ABSTRACT
Retinoic acid, an active metabolite of vitamin A, exerts multiple effects on regulating embryonic development and inducing differentiation, proliferation, apoptosis as well as resistance in various cancer cells. Apart from the classic genomic action (binding to the nuclear receptors to regulate the expression of its downstream target genes), retinoic acids also play important roles in anti-cancer effect through non-genomic pathways (via extranuclear and non-transcriptional effects).
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Tretinoína
/
Diferenciação Celular
/
Apoptose
/
Receptores do Ácido Retinoico
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Genômica
/
Tratamento Farmacológico
/
Neoplasias
Limite:
Humans
Idioma:
Zh
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2019
Tipo de documento:
Article