Automated synthesis of 2-(18)F-fluoro-2-deoxy-D-glucose by on-column hydrolysis / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 1151-1156, 2009.
Article
em Zh
| WPRIM
| ID: wpr-814179
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To study automated synthesis of 2-[(18)F]-fluoro-2-deoxy-D-glucose ((18)F-FDG) via on-column hydrolysis.@*METHODS@#Automated synthesis of (18)F-FDG was performed by the on-column hydrolysis procedure in TRACERlab FXF-N synthesizer. (18)F-FDG injection was obtained via nucleophilic fluorination of 1, 3, 4, 6-tetra-O-acetyl-2-O-trifluoromethanesulfony-beta-D-mannopyranose as the precursor molecule with (18)F-fluoride, hydrolysis of the (18)F-labeled intermediate on SEP-PAK C18 cartridges with 2 mol/L NaOH solution, and purification and neutralization with SEP-PAK cartridges.@*RESULTS@#The uncorrected radiochemical yield of (18)F-FDG was more than 60% within the total synthesis time shorter than 20 min. The radiochemical purity of (18)F-FDG was above 99%.@*CONCLUSION@#On-column hydrolysis is simple and practical for the automated synthesis of (18)F-FDG. (18)F-FDG injection produced by this procedure can be used in clinical PET imaging.
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Base de dados:
WPRIM
Assunto principal:
Automação
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Diagnóstico por Imagem
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Radiografia
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Compostos Radiofarmacêuticos
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Fluordesoxiglucose F18
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Tomografia por Emissão de Pósitrons
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Hidrólise
/
Neoplasias Renais
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Neoplasias Hepáticas
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Métodos
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
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Aged
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2009
Tipo de documento:
Article