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Basic experimental and clinical research on peritoneal dialysis in the past 16 years / 中南大学学报(医学版)
Article em Zh | WPRIM | ID: wpr-814214
Biblioteca responsável: WPRO
ABSTRACT
To summarized the experiences from our basic experimental and clinical research on peritoneal dialysis. In the past 16 years, peritoneal fibrosis rat models and rabbit models of peritonitis were first established successfully in our laboratory in China. Peritoneal mesothelial cells were also separated and identificated. Besides, we assessed the biocompatibility of peritoneal dialysis fluid and analyzed the molecular mechanism of peritoneal mesothelial cell injury. We demonstrated the key role of transforming growth factor-beta1 (TGF-beta1), connective tissue growth factor (CTGF) and peroxisome proliferative activated receptor-gamma (PPAR-gamma) in the pathogenesis of peritoneal fibrosis, as well as their regulation of molecular mechanism. Furthermore, we transfected the plasmids encoding TGF-beta1-shRNA or pCTGF-shRNA into peritoneal cells and tissues by nanocarrier technologies. In clinical research, the positioning of peritoneal dialysis catheters, peritoneal dialysis treatment modalities and the prevention and treatment of its complications were studied. The characteristics and mechanism of solute transport in peritoneal dialysis was also explored.
Assuntos
Texto completo: 1 Base de dados: WPRIM Assunto principal: Patologia / Peritônio / Terapêutica / Fibrose / Aderências Teciduais / Estudos Retrospectivos / Fator de Crescimento Transformador beta / Diálise Peritoneal / Diálise Peritoneal Ambulatorial Contínua / Fator de Crescimento do Tecido Conjuntivo Tipo de estudo: Observational_studies / Prognostic_studies Limite: Animals / Humans Idioma: Zh Revista: Journal of Central South University(Medical Sciences) Ano de publicação: 2009 Tipo de documento: Article
Texto completo: 1 Base de dados: WPRIM Assunto principal: Patologia / Peritônio / Terapêutica / Fibrose / Aderências Teciduais / Estudos Retrospectivos / Fator de Crescimento Transformador beta / Diálise Peritoneal / Diálise Peritoneal Ambulatorial Contínua / Fator de Crescimento do Tecido Conjuntivo Tipo de estudo: Observational_studies / Prognostic_studies Limite: Animals / Humans Idioma: Zh Revista: Journal of Central South University(Medical Sciences) Ano de publicação: 2009 Tipo de documento: Article