Effect of neoadjuvant chemotherapy on cervical carcinoma / 中南大学学报(医学版)

ABSTRACT

OBJECTIVE@#To investigate the effect of neoadjuvant chemotherapy on cervical carcinoma and its association with clinical data.@*METHODS@#A total of 97 patients with stage Ib2 approximately IIIa of cervical cancinoma were treated with neoadjuvant chemotherapy. The effect of chemotherapy, factors associated with outcome of chemotherapy, and histology were analyzed.@*RESULTS@#Effective rate of chemotherapy was 86.6% which was associated with clinical stage and histology. Eight-four patients received radical hysterectomy. The histological grade of 17 patients was lowered, lymph nodes in 19 patients were positive, and 6 patients had parametrium invasion. One patient died within 1 year after the operation, and 5 patients recurred.@*CONCLUSION@#The effect of neoadjuvant chemotherapy for locally advanced cervical cancinoma is good. Surgery after chemotherapy can improve the prognosis and 5-year survival rate.