Inflammatory factors promote the development of colorectal cancer / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 646-649, 2011.
Article
em Zh
| WPRIM
| ID: wpr-814538
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To study the change of inflammatory factors at different stages of colorectal cancer (CRC).@*METHODS@#Thirty normal subjects, 30 patients with colorectal adenomatous polyps and 120 CRC patients at different stages were enrolled. IgG, IgM, and IgA levels, the inflammatory cytokines IL-2, 4, 6, 10, and 12 and the expression of TGF-β 1 and VEGF in the serum were analyzed by ELISA or immunoturbidimetry.@*RESULTS@#The serum concentrations of IL-12, TGF-β 1, and IL-6 in the CRC patients were statistically different compared with the normal and adenomatous polyps, and increased as the disease progressed (P0.05). The serum level of IgG, IgM, and IgA in the 3 groups showed no significant difference (P>0.05).@*CONCLUSION@#The serum level of inflammatory cytokines TGF-β 1, IL-6, and IL-12 increases gradually with the development of CRC, which may change the microcirculation of patients with CRC, and promote the development of CRC.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Sangue
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Imunoglobulinas
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Neoplasias Colorretais
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Citocinas
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Interleucina-6
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Pólipos Adenomatosos
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Interleucina-12
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Alergia e Imunologia
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Fator de Crescimento Transformador beta1
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Inflamação
Limite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2011
Tipo de documento:
Article